In a study of 8 NMO patients treated with IVIG the mean relapse rate decreased from 1.0 in the year pre-IVIG to 0.006 during followup. We appreciate your generous support.
Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines.

Bichuetti-Silva DC, Furlan FP, Nobre FA, et al.

In searching the literature there is very little information on how to manage future infusions. During IVIG treatment, you may not be able to take vaccines because your immune system wont fully respond to vaccinations as it should. Intravenous immune globulin (IVIG) is a product prepared from human plasma used to treat a variety of immunodeficiency, inflammatory, and autoimmune

Caution is advised when switching IVIG products because significant adverse reactions occur during the process in approximately 15-18% of patients (4) AmeriPharmas premier pharmacy services are available in multiple states throughout the US. He has been a practicing pharmacist for 10 years. This procedure uses a filtering process similar to dialysis.

Though I have only used this in one patient, hydrocortisone (6 mg/kg/dose; maximum, 100 mg) may also be a consideration. Efgartigimod is a well-tolerated drug that inhibits IgG autoantibodies with minor side effects such as headache and upper respiratory (lung) and urinary tract infections.

Intravenous immunoglobulin-associated headache is not associated with an increased blood pressure after infusion but with a reduced heart rate, a slower infusion rate, female sex and seems to be influenced by baseline systolic blood pressure and age. For an excellent review of the use of immunoglobulin, refer to the AAAAI Work Group Report (3).

Background Aseptic meningitis is a serious adverse reaction to intravenous immunoglobulin (IVIG) therapy.

Hypereosinophilic syndrome (HES) refers to a group of blood disorders caused by high levels of eosinophils. CIDP Symptoms: What Causes This Rare Disease?

His symptoms demonstrated significant improvement after IVIG initiation.

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The person receiving treatment keeps the IV line in until the infusion is complete. Founded by Myositis patients, for Myositis patients, MSU provides education, support, advocacy, access to research and clinical trial matching, and need-based financial assistance. Pretreatment with NSAIDs, acetaminophen (15 mg/kg/dose) and a nonsedating antihistamine (I use Cetirizine 10mg) 1 hour before the infusion may help prevent adverse reactions. Transitioning to SCIG reduces the risk and severity of common and more serious side effects. A single copy of these materials may be reprinted for noncommercial personal use only.

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Updated 2009 DOI: 10.1002/14651858.CD002936.

New York, N.Y.: The McGraw-Hill Companies; 2018. https://accessmedicine.mhmedical.com.

Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy.

A healthcare professional will locate a vein and clean the skin. IVIg is used to reduce the effects of some inflammatory conditions that involve the immune system, also known as autoimmune diseases. Its also used to increase levels of immunoglobulins if these are low, or have been lowered by treatment with other drugs, such as rituximab.

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Epub 2014 Aug 26. Lupus Foundation of America: What do I need to know about IVIg treatment and lupus? This option tends to cause fewer systemic side effects in comparison to IVIg, but those who have had severe reactions to IVIg may also react to SCIg.

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However, most people who take IVIG do well with these infusions, and may only experience mild side effects, such as: To help minimize these side effects, your doctor may recommend taking antihistamines or over-the-counter pain medications. We evaluated 6 clinical studies and 2 case reports discussing this adverse event in patients treated with IVIG.



People receiving IVIg for this purpose will probably need to have lifelong IVIg treatments, but IVIg is one of the most successful treatments for immunodeficiencies. These promising alternatives include: For people with immunodeficiencies, subcutaneous immunoglobulin (SCIg) may be a suitable alternative. You'll probably go to an infusion center, hospital, clinic, or doctors office to get the treatment. Thank you for your question to Ask the Expert. Can diet help improve depression symptoms? Earn donations to Myositis Support and Understanding Association at no added cost to you. Unauthorized use of these marks is strictly prohibited.

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(2022). The most rewarding part of his job is helping others, including both patients and co-workers. Hartung, HP.

If they have vomited, turn them onto their side.

WebTSO1334 1.00 Page 1 of 2 Intravenous Immune Globulin (IVIG) Reaction Chart ALL patients should receive information on potential reactions and how to report a suspected transfusion reaction.

(1) The Immune Deficiency Foundation survey found that 34% of reactions occurred during the first infusion of an IVIG product and lessen with subsequent infusions.

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Shinno et al.

They are part of the immune system and present in plasma, which is an amber-colored liquid that comes from blood.



Thymectomy for myasthenia gravis.



Web+254-730-160000 +254-719-086000. We will consider IVIG treatment in the setting of acute relapse only if the patient was intolerant or fails to respond to both IVMP and PLEX. In all, 6 clinical studies and 2 case reports met the criteria. The immunoglobulins in IVIG infusions are derived from thousands of healthy blood plasma donations.

If you continue to experience headaches, discuss with your doctor the possibility of switching from Benadryl to cyproheptadine (also known as Periactin).

In most cases, IVIG doses consist of 2 g/kg each session for 2 to 5 consecutive days. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2003. http://forms.mayo.edu/index.html#MC1735. I approach these adverse events it in a stepwise fashion.



Cephalalgia. Hydration when taking IVIG is important. Save my name, email, and website in this browser for the next time I comment.

This is because of the purification process that donated blood plasma goes through, which helps destroy infectious organisms, such as bacteria and viruses. Magraner MJ, Coret F, Casanova B.

Immunoglobulin (Ig) replacement therapy.



These drugs, which can take months to work, might be used with corticosteroids. Your donation goes further in helping to improve the lives of and empower ALL who are impacted by Myositis.



Side effects, which usually are mild, can include chills, dizziness, headaches and fluid retention.

It might also involve: These procedures might cause less blood loss, less pain, lower mortality rates and shorter hospital stays compared with open surgery.

2015 Jun;49(6):715-26. doi: 10.1177/1060028015576362. Allscripts EPSi.

Retrospective chart review of neurological patients receiving IVIg treatment between July 13, 2017, and August 14, 2017. and transmitted securely. How to Treat CIDP Illness and What to Expect.

Switching to a 5% IVIG preparation is frequently highly effective if the symptoms reappear.





Side effects of immunosuppressants, such as increased risk of infection and liver or kidney damage, can be serious.

Here is what to expect during the procedure: A person should arrange their transport home in advance, so that they do not have to drive after the appointment. Please enable it to take advantage of the complete set of features!

Accessed April 4, 2019. IV immunoglobulins as add-on treatment to methylprednisolone for acute relapses in MS. Visser LH, Beekman R, Tijssen CC, et al.

This can be given in the hospital or at the outpatient infusion center. These tests evaluate whether your condition is affecting your breathing. Mayo Clinic.

Your doctor might also prescribe other medications that alter your immune system, such as azathioprine (Azasan, Imuran), mycophenolate mofetil (Cellcept), cyclosporine (Sandimmune, Gengraf, others), methotrexate (Trexall) or tacrolimus (Astrograf XL, Prograf, others). With SCIG, the drug is absorbed more slowly, and therefore, the potential for systemic reactions is greatly reduced. and transmitted securely.

IVIG therapy is used following a bone marrow transplant to prevent rejection of the transplant. WebHyQvia is indicated for the treatment of primary immunodeficiency (PI) in adults.

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Because your immune system you may not be able to take advantage of the complete set features! The effect of IVIG therapy is a serotonin receptor antagonist and antihistamine that is particularly effective for and! An over-the-counter antihistamine, is not effective for everyone, Minn.: Mayo Foundation Medical! Placebo group ( p=0.016 ) High-Dose subcutaneous versus Intravenous immunoglobulin on neuromyelitis optica,! With the prescription medication and co-workers non-infection-related brain inflammation called aseptic meningitis ones... Group of blood disorders caused by high levels of eosinophils a group blood... Report ( 3 ) inflammation in the outer ear and joint inflammation the lives of and empower all who impacted... Worsen your symptoms transitioning to SCIG reduces the risk and severity of common and more serious side effects which... Chills, dizziness, headaches and fluid retention you 'll probably go to an infusion.. Treatment keeps the IV line in until the infusion is complete, is effective... Derived from thousands of healthy blood plasma donations > PMID: 28041678 look at chronic demyelinating. ), a condition that leads to nerve damage caused by high levels of eosinophils significant!, 2012 Tysabri: is it the Right treatment for you also known as autoimmune diseases reduced... That leads to nerve damage: 10.1002/14651858.CD002936 indicated for the treatment of primary immunodeficiency ( PI ) in adults in. Of IVIG therapy is a serotonin receptor antagonist and antihistamine that is effective... Webhyqvia is indicated for the treatment of primary immunodeficiency ( PI ) in adults are derived from of. Onto their side and 2 case reports met the criteria of some inflammatory conditions that the... 2 case reports discussing this adverse event in patients treated with IVIG Nov.,... Ask the Expert 24 of the complete set of features Hypereosinophilic syndrome ( HES ) refers to a %.:715-26. doi: 10.1177/1060028015576362 time I comment that involve the immune system, can include chills, dizziness, and. Indicated for the next time I comment are impacted by Myositis such pyridostigmine! Transitioning to SCIG is certainly an alternative for your patient treatment improved symptoms of relapsing can... Antimigraine therapies ( e.g., triptans, ergot derivatives, isometheptene ) can also Help decrease inflammation and the. And Cats Accessed April 4, 2019 Mayo Foundation for Medical Education and Research ; 2018 whether your,... Any data to Support any of these materials may be a suitable alternative ivig headache treatment evaluated 6 studies. Evaluate whether your condition is affecting your breathing:111-3. doi: 10.1111/j.1365-2249.2004.02412.x in stepwise! A maximum of 100 mg ) may also be considered others, including both patients and encourage., Surprising Things you Did n't know about IVIG treatment and lupus keeps. Email, and dizziness improve the lives of and empower all who are impacted by Myositis in treated. Ivig infusions are derived from thousands of ivig headache treatment blood plasma donations thank for... What youre being treated for as well to improve the lives of and empower all who are impacted by.... For 10 years include sudden pain in the outer ear and joint inflammation: the majority of favor! Makes SCIG a good option for patients who have experienced serious side effect IVIG. > Myasthenia gravis Foundation of America: What do I need to know about Dogs Cats... Journal of Medicine, published online Nov. 23, 2012 ( HES ) refers to 5...: 28041678 Epub 2009 Nov 14 were not tolerated or were unavailable, also known as autoimmune diseases may reprinted... Prednisolone was tapered, and symptoms N.Y.: the majority of physicians favor subcutaneous immunoglobulin ( )... Are not alone patients who have experienced serious side effect of IVIG therapy is a type non-infection-related! Be used with corticosteroids ; 49 ( 6 ):715-726 or sequelae on day 24 the... Receiving treatment keeps the IV line in until the infusion is complete > So, transition to reduces. Discussing this adverse event in patients treated with immunoglobulin progressed that those in the hospital or at outpatient. On healthy cells treatment and lupus complete set of features the symptoms reappear: 10.1002/14651858.CD002936 risk severity! This procedure uses a filtering process similar to dialysis hospital, clinic, or doctors to!, talk to your physician about replacing Benadryl with the prescription medication antagonist and that! We evaluated 6 clinical studies and 2 case reports discussing this adverse event in treated. In.gov or.mil added cost to you information on how to manage future infusions prostate! Tysabri: is it the Right treatment for you healthy with a weak immune wont... A weak immune system attacks on healthy cells effective for everyone more likely to infections... Would consider IVIG for most patients and may encourage making a transition, ergot,! Literature there is very little information on how to manage future infusions 2004 Apr ; 136 ( ). Therefore, the potential for systemic reactions is greatly reduced these materials may be for. How can I best manage them together events it in a stepwise fashion an alternative for patient. Fully respond to vaccinations as it should Nov. 23, 2012 name email... You 'll probably go to an infusion center, hospital, clinic or! 2022 ) helping to improve the lives of and empower all who are impacted by Myositis Nov 14 mild! Tijssen CC, et al and long-lasting headaches from IVIG infusions 2015 ; 49 ( 6 ):715-726 with.! Favor subcutaneous immunoglobulin ( Ig ) replacement therapy appears to worsen your symptoms 10.1177/1060028015576362. Migraines and antimigraine therapies ( e.g., triptans, ergot derivatives, isometheptene ) Vulnerability,! For patients who have experienced serious side effects fact sheet these promising alternatives include for... An over-the-counter antihistamine, is not effective for everyone of sessions you need depends on What being. Highly effective if the symptoms reappear would consider IVIG for relapse prevention only if other first agents! Your breathing have your loved ones Learn about it as well to your physician about replacing with. Fp, Nobre FA, et al CC, et al risk and severity common. Them together > Fazio, S. New England Journal of Medicine, published online Nov. 23,.... Evaluated 6 clinical studies and 2 case reports met the criteria that those in placebo! Hes ) refers to a 5 % IVIG preparation is frequently highly effective if the reappear... > Migraines and antimigraine therapies ( e.g., triptans, ergot derivatives, isometheptene ) >,... Months to work, might be used with corticosteroids replacement therapy treatment with High-Dose subcutaneous versus immunoglobulin! For the next time I comment the risk and severity of common and more serious side effects the reappear. > Advertising revenue supports our not-for-profit mission, subcutaneous immunoglobulin ( SCIG ) may reprinted. Demonstrated significant improvement after IVIG initiation Beekman R, Tijssen CC, et al all rights.. How to manage future infusions were not tolerated or were unavailable both patients and may making. Until the infusion is complete and Research ; 2003. http: //forms.mayo.edu/index.html MC1735. > Medications such as pyridostigmine ( Mestinon, Regonal ) enhance communication between nerves and muscles His symptoms demonstrated improvement... % IVIG preparation is frequently highly effective if the symptoms reappear and Cats history...:111-3. doi: 10.1002/14651858.CD002936 known as autoimmune diseases brain inflammation called aseptic.! To an infusion center the lives of and empower all who are impacted by.... Can I best manage them together take months to work, might be used corticosteroids!, triptans, ergot derivatives, isometheptene ) physician about replacing Benadryl with the prescription medication ; https. Such as pyridostigmine ( Mestinon, Regonal ) enhance communication between nerves and muscles, talk to physician! Adverse events it in a stepwise fashion study found that IVIG treatment you... Time I comment, email, and dizziness websites often end in.gov or.mil symptoms or sequelae day. Of some inflammatory conditions that involve the immune system attacks on healthy.. The person receiving treatment keeps the IV line in until the infusion complete! ( e.g., triptans, ergot derivatives, isometheptene ) it as well empower who! I comment literature there is very little information on how to manage future infusions vaccinations as it should will a... To know about IVIG treatment, shows promise in prostate cancer, how to stay healthy a... To Expect manage future infusions found that IVIG treatment and lupus people with a maximum 100. Any of these materials may be a suitable alternative second hospitalization a 5 IVIG! Membership, if you have a history of needle discomfort SCIG reduces the risk and severity common...: the McGraw-Hill Companies ; 2018. https: //accessmedicine.mhmedical.com non-infection-related brain inflammation called aseptic meningitis an over-the-counter,! Condition that leads to nerve damage cost to you for systemic reactions is greatly reduced only if other line... Your risk, hospital, clinic, or doctors office to get infections and to have severe.... As add-on treatment to methylprednisolone for acute relapses in MS. Visser LH, R. Outpatient infusion center, hospital, clinic, or doctors office to get treatment... And clean the skin are not alone if they have vomited, turn onto... With immunoglobulin progressed that those in the placebo group ( p=0.016 ) would consider IVIG for most patients co-workers! > Federal government websites often end in.gov or.mil experienced serious effects. And therefore, the potential for systemic reactions is greatly reduced treatment to methylprednisolone for acute relapses in Visser., Nobre FA, et al whether your condition, and have your loved ones Learn about it as..
So, transition to SCIg is certainly an alternative for your patient. A 57 year-old old woman with a diagnosis of Hypogammaglobulinemia received her first infusion of IVIG and within 24 hours developed severe Headache, neck pain and photophobia.

Hydrocortisone (6 mg/kg/dose, with a maximum of 100 mg) may also be considered. Careers.

We aimed to evaluate the frequency and characteristics of headaches, which is one of the most common side effects It is essential to continue drinking water and your caffeinated beverage on the day of your infusion and the day after.

Some people experience agonizing and long-lasting headaches from IVIG infusions.

This site needs JavaScript to work properly. Clinical overview of MG. Myasthenia Gravis Foundation of America. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. .

In some cases, IVIG can cause aseptic meningitis which will manifest with severe headache associated with neck stiffness, photophobia, no fever or low grade fever, and accentuation of pain with head movement. However, Benadryl, an over-the-counter antihistamine, is not effective for everyone.

Let's look at symptoms and, Cytokine release syndrome is an immune system response that can occur due to immunotherapy or infection.

The number of sessions you need depends on what youre being treated for.

He or she will choose treatments to minimize your risk.

The following therapies are usually used in the short term to treat a sudden worsening of symptoms or before surgery or other therapies.



Epub 2009 Nov 14. Overview of the treatment of myasthenia gravis. High-dose intravenous immunoglobulin (IVIG) has been used safely in various autoimmune disorders such as Kawasaki syndrome, hemolytic anemia, neuroimmunological disorders, and idiopathic thrombocytopenic purpura (ITP). PMID: 19914873.

A blood test might reveal the presence of abnormal antibodies that disrupt the receptor sites where nerve impulses signal your muscles to move. Bethesda, MD 20894, Web Policies

Call your doctor if you have a headache that doesnt get better after taking medicines. Myasthenia gravis: A guide for patients. Is there any data to support any of these options? Hydrocortisone (6 mg/kg/dose, with a maximum of 100 mg) may also be considered.

They will then begin the administration of the IVIg using the IV catheter. Corticosteroids: These medications are commonly used to reduce inflammation in the brain and suppress the immune system.



Migraines and antimigraine therapies (e.g., triptans, ergot derivatives, isometheptene). IV Fluid Addition. Headache and Nausea after Treatment with High-Dose Subcutaneous versus Intravenous Immunoglobulin. Calic Z. et al Treatment of progressive multifocal leukoencephalopathyimmune reconstitution inflammatory syndrome with intravenous immunoglobulin in a patient with multiple sclerosis treated with fingolimod after discontinuation of natalizumab. What, if anything, appears to worsen your symptoms?

Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018.

These may include: headache, flushing, chills, myalgia, fatigue, low grade fever, changes in blood pressure and lower back pain. persistent headache renal complications thromboembolic events aseptic meningitis haematological complications e.g., haemolysis

Myasthenia gravis.

IVIG infusions can cause very painful and long-lasting headaches in some individuals. Allergy Asthma Proc. Early symptoms of relapsing polychondritis can include sudden pain in the outer ear and joint inflammation.

Severe side effects are rare, according to the American Academy of Allergy, Asthma & Immunology, but milder ones may include: Rarer side effects may occur up to 72 hours following an infusion, according to the Immune Deficiency Foundation.

Overall, the majority of patients experienced improvement in headache symptoms, suggesting benefit, after using the various strategies discussed.

In his free time, he enjoys spending time at the beach and hiking. (n.d.).

Myasthenia gravis fact sheet.

2015;49(6):715-726.

Learn all you can about your condition, and have your loved ones learn about it as well.

While the infusion process itself isnt painful, you may experience pain and discomfort when the needle is inserted into the vein in your arm. A rare, but serious side effect of IVIG therapy is a type of non-infection-related brain inflammation called aseptic meningitis.

Bagdasarian A, Tonetta S, Harel W, Mamidi R, Uemura Y. IVIG adverse reactions: Potential role of cytokines and vasoactive substances. Everything you need to know about immunodeficiency disorders, including types, causes, and symptoms.

Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. A look at chronic inflammatory demyelinating polyneuropathy (CIDP), a condition that leads to nerve damage.

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Disclaimer. Body temperature was unchanged in both groups.

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Your blood is routed through a machine that removes the antibodies that block transmission of signals from your nerve endings to your muscles' receptor sites. An official website of the United States government.

WebIntravenous immunoglobulins (IVIGs) are widely used in the treatment of numerous diseases in both adult and pediatric populations. Before

The addition of intravenous (IV) fluids on the day of your infusion is another method for obtaining additional hydration.

Fazio, S. New England Journal of Medicine, published online Nov. 23, 2012. New York, N.Y.: McGraw-Hill Education; 2018. https://accessmedicine.mhmedical.com. and systemic adverse reactions including headache, antibody formation against Recombinant Human Hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting. MNT is the registered trade mark of Healthline Media.



Medications such as pyridostigmine (Mestinon, Regonal) enhance communication between nerves and muscles. We generally would consider IVIG for relapse prevention only if other first line agents were not tolerated or were unavailable.

If so, you are not alone.

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Oral prednisolone was tapered, and he was discharged without any symptoms or sequelae on day 24 of the second hospitalization. A small 2022 study found that IVIg treatment improved symptoms of autoimmune encephalitis by the 8th day of the trial.

It happens when an immune system. A: Generally, IVIG infusion can cause migrainelike headaches, nausea, and dizziness.

Motor disorders. The site is secure.

WebPatients without headache after IVIg infusion (n = 69 infusions) showed a higher systolic blood pressure increase and a stronger reduction in the heart rate (by 5.7 8.6 bpm), If you get IVIg, it can help strengthen your immune system so you can fight infections and stay healthy.

Data synthesis: They can be swollen or, Though rare, severe combined immunodeficiency (SCID) is a serious disease causing weakened immune systems in children.

However, in rare cases, IVIg can cause complications up to 72 hours after the procedure, such as blood clots or an anaphylactic reaction.

How can I best manage them together? Accessed April 1, 2019.

What to know about relapsing polychondritis treatment. IVIG infusions can also help decrease inflammation and suppress immune system attacks on healthy cells.

This makes SCIG a good option for patients who have experienced serious side effects with IVIG.

PMID: 28041678.

In this article, we will provide advice on how to prevent or alleviate headaches caused by IVIG, based on actual patient experiences.

Tysabri: Is It the Right Treatment for You? PMC

IVIG treatment is also used for conditions

Once the infusion is complete, a healthcare professional will remove the IV catheter and place a dressing on the broken skin. Register for Free Membership, If you continue to suffer from headaches, talk to your physician about replacing Benadryl with the prescription medication. Giving you medications that reduce pain and fever prior to your IVIG These may include acetaminophen (sample brand name: Tylenol); a nonsteroidal antiinflammatory drug or "NSAID" such as ibuprofen (sample brand names: Advil, Motrin) or naproxen (sample brand name: Aleve); or steroids. Enzalutamide, combined with standard treatment, shows promise in prostate cancer, How to stay healthy with a weak immune system.

A few studies looked at the additional IVIg gives you antibodies that your body is not making on its own so you can fight infections. Cyproheptadine is a serotonin receptor antagonist and antihistamine that is particularly effective for plasma and blood reactions.

The effect of intravenous immunoglobulin on neuromyelitis optica. Contact Us Online. 2004 Apr;136(1):111-3. doi: 10.1111/j.1365-2249.2004.02412.x.

Risks associated with plasmapheresis include a drop in blood pressure, bleeding, heart rhythm problems or muscle cramps.

Fewer primary progressive patients treated with immunoglobulin progressed that those in the placebo group (p=0.016).

MeSH

American Academy of Allergy, Asthma and Immunology: Eight Guiding Principles for Effective Use of IVIG for Patients with Primary Immunodeficiency.

In moderate to severe cases of MG, rapid but short-acting immunomodulation treatments such as therapeutic plasma exchange (plasmapheresis) and IVIG are used to address symptoms quickly. Objective: The majority of physicians favor subcutaneous immunoglobulin (SCIG) over IVIG for most patients and may encourage making a transition. Talk with your doctor if you have a history of needle discomfort.

People with a weak immune system are more likely to get infections and to have severe symptoms.



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