Manuscripts are accepted for publication on the basis of scientific merit practical significance and suitability for publication in a journal dedicated to this discipline. An unequivocal, benign diagnosis was rendered by FNAC in 80 cases, 67 of which were correctly labelled as neurilemoma in a review of the original cytology reports. Early diagnosis and treatment prevents the more severe manifestation of the disease, lymphatic filariasis. In conclusion, the implementation of SCNB did not result in a decrease in the total number of breast FNAs; however, the distribution of cases changed. Eight of the 16 patients (50%) had a diagnosis of ACC, four (25%) had salivary duct carcinomas, two (12.5%) had MECs, one (6.25%) was a basaloid tumor, and one (6.25%) was polymorphous low grade adenocarcinoma. One hundred and twenty-two fine needle aspirates (FNA) from female patients were studied to determine whether CA-125 assay contributed to cytologic diagnosis and CEA assay. Forward stepwise logistic regression analysis of the 150 tumors revealed that only PWs and cervical involvement were independently predictive of TWs. Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors. CD-15 and CA 19-9 are less sensitive but more specific. The cytoplasm of the tumor cells was strongly stained with neuron-specific enolase antibody. The relationship between adolescence and HPV infections appears to be stronger for HPV 18 and mixed HPV 16/18 infections (OR = 5.6; 95% CI = 0.7-42.4) than for HPV 16 infections (OR = 1.93; 95% CI = 0.4-8.8). A series of 25 cases of aspirates from breast cancer were analyzed with this methodology. We conclude that FNA in conjunction with FC can be used as the initial diagnostic approach for both primary and recurrent hematopoietic processes. Although carefully collected, accuracy cannot be guaranteed. If still in doubt, the diagnosis can be substantiated by supplementary immunocytochemical examinations. FN predicts a higher rate for neoplasm but an intermediate rate for malignancy while SM carries a high risk for malignancy. We conclude that the cytologic features of SAT are predictable, particularly, in the appropriate clinical setting. Direct smears were immediately stained with Diff-Quik and Papanicolaou and assessed for specimen adequacy (criteria as followed in this institution). While elevated CEA enhances the sensitivity of cytologic diagnosis of carcinomas of the colon, pancreas, and lung, low CEA and high CA-125 content supports an ovarian/endometrial primary. The incidence of adenocarcinoma of the cervix is increasing within the US, but this diagnostic category is not typically associated with teenaged patients. 21-day rapid review process with international peer-review standards. Click the Chrome menu icon in the top right of the browser. This rare case presentation gives us the opportunity to review the differential diagnosis of adolescent breast lesions. We evaluated Papanicolaou (Pap) smears and cervical tissue specimens from a consecutive series of 25 adolescent (age 15-20 yr) and 17 adult (age 35-40 yr) patients with a histologic diagnosis of CIN III. This study also illustrates that FNA cytology of ovarian cysts can play a role in the detection of occult ovarian neoplasms in the IVF patients population. Digital pathology in diagnostic cytopathology 2 nd International Conference on Cytopathology & Histopathology … Identification of the parasite, Wuchereria bancrofti, in FNA smears and accurate diagnosis of filaria is important to employ proper treatment. It is concluded that retrograde transtubal spread by malignant endometrial cells occurs independently of myometrial histoprognostic features. You must have Java installed, cookies enabled, and pop-up blockers disabled to use the site. These are relatively rare disease processes about which many cytopathology professionals may be unfamiliar. Diagnostic accuracy of FNA for NHL improved to 98.0% following review. In this staining procedure after detection of the biotin-labeled alpha-satellite probe for chromosome 17 with avidin-biotin-peroxidase, we incorporated a signal amplification based on the peroxidase-catalyzed deposition of a biotinylated phenolic compound followed by a secondary reaction with peroxidase. In addition, new aspects of morphologic and immunocytochemical characteristics of the cells as well as genetic markers may soon become powerful tools for practical use. This retrospective study was designed to evaluate the accuracy of cytopathologic diagnosis and of correct classification of benign breast diseases. We describe a method of in situ hybridization (ISH) to assess numerical chromosome abnormalities on alcohol-fixed smears obtained by fine-needle aspiration from breast cancer patients, using a commercially available amplification kit to demonstrate numerical chromosome alterations of chromosome 17. Four FN surgical biopsies (8.3%) were sampling errors. Positive cytologic results diagnosed malignancies in 49.3%. Diagn. We did not find concordance between numerical chromosome abnormalities of chromosome 17 and nuclear grading as well as with the immunoexpression of p53 and c-erbB2 studied in the smears. The study patients were all Detroit residents enrolled in a health maintenance organization (HMO) affiliated with Henry Ford Hospital. All patients had mid- or upper-cervical lymphadenopathy (14 bilateral, 3 unilateral). One of the various histomorphologic patterns of infections is the granuloma, which sometimes may be difficult to diagnose cytologically. Data provided are for informational purposes only. Interobserver variability was assessed using Cohen's Kappa (K) coefficient. The exact underlying nature of 66 cysts could not be determined as the aspirates consisted of foamy macrophages only. JDPO - IP J Diagn Pathol Oncol- Print ISSN No:-2581-3714 Online ISSN No:-2581-3706,Journal of Diagnostic Pathology and Oncology (JDPO) is open access, double-blind peer-review journal … FNA cytology revealed pleomorphic oval cells with prominent nucleoli along with spindle cells, tumor giant cells, and a chondromyxoid background. Imaging studies using the fluoride-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scan have recently become available for patient neoplasia evaluation. Fine needle aspiration (FNA) has proven to be an effective tool in management of patients with thyroid nodules. Five follicular carcinomas were identified histologically in the SFN category, all minimally invasive. To do so, the cytology of 148 breast FNAs that had been prepared by the cytospin technique and that had histologic correlation, was reviewed. Eight aspirates derived from 4 different patients contained neoplastic cells and, of these, one patient was later found to have a serous cystadenocarcinoma of low malignant potential, while another had a serous cystadenoma. FNA is increasingly used to complete the triple test in clinically and radiographically negative cases. We report on our experience in fine-needle aspiration (FNA) biopsy of the retroperitoneum: 111 FNA biopsies performed on 99 patients. Overt malignancy, a cystic papillary carcinoma, was identified histologically in only one case of BFN, for a negative predictive value of 98.7%. This both facilitates and expedites the submission… All FNAs and all available correlating surgical pathology reports were reviewed. In all cases, the aspirates were procured by cytopathologists using 22- or 23-gauge needles. The diagnosis of retinoblastoma was confirmed. For Revised manuscripts… The sensitivity, specificity, positive predictive value, and negative predictive value were 90%, 79%, 92%, and 82% in the pre-SCNB group and 93%, 86%, 91%, and 90% for the post-SCNB group, respectively. One case was insufficient for diagnosis by FNA and six cases were inadequate for FC. Positive cytological results, especially of the cerebrospinal fluid. Please also verify the web address entered in your browser's address bar. Generally, Giemsa but not Pap stain is used in FNAC. The cell block was found to be the most useful in diagnosis. A study of 1,798 endometrial cytological samples, obtained with an "endocyte" (a disposable scraping device) and controlled in histology is presented. The manuscript … In addition, the utility of adjunctive techniques was analyzed and other spindle-cell lesions in the differential diagnoses were discussed. Specific diagnosis was correct on average in 50% of cases, only in FA was its accuracy over 60%; in adequately sampled tumor, the predictive value of FA was 86.2%. A leading journal selection tool is available free of charge for authors to find the best fit for their manuscript. To avoid contamination of equipment and reduce risks of infection, intraoperative cytology (IOC) is a useful substitute to conventional frozen section in the diagnosis of infectious diseases. @ScholarOneNews 29 benign, 93 malignant. Compared to surgical biopsy (48 cases) and clinical data, the sensitivity and specificity of FNA for malignancy was 95.1% and 100%, respectively, yielding a positive predictive value of 100% and a negative predictive value of 88.8%. The corresponding figures were 16.6%, 18.4%, and 60.1%, respectively, in cytology. 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